/* MD Semaglutide — clinical-dashboard archetype
   Slate-blue + warm taupe + terracotta on cream
   Space Grotesk headings / Inter body / JetBrains Mono data */

:root {
  --primary: #243B53;
  --primary-50: #EAF0F6;
  --primary-900: #0E1E2F;
  --secondary: #8B6F47;
  --accent: #B7410E;
  --neutral-50: #F7F6F3;
  --neutral-200: #E4E2DC;
  --neutral-500: #6B6862;
  --neutral-900: #1A1916;
  --bg: #F7F6F3;
  --surface: #FFFFFF;
  --text: #1A1916;
  --text-muted: #6B6862;
  --success: #3F6E4A;
  --warning: #A37320;
  --danger: #9B2C2C;

  --max-width: 76rem;
  --container-px: clamp(1rem, 3vw, 2.5rem);

  --font-heading: 'Space Grotesk', 'Neue Haas Grotesk', 'Helvetica Neue', Helvetica, Arial, sans-serif;
  --font-body: 'Inter', system-ui, -apple-system, 'Segoe UI', sans-serif;
  --font-mono: 'JetBrains Mono', 'IBM Plex Mono', 'SF Mono', Consolas, monospace;

  --radius-button: 2px;
  --radius-card: 4px;
  --radius-tag: 2px;

  --rule: 1px solid var(--neutral-200);
  --rule-strong: 1px solid var(--primary);
}

/* Reset */
*, *::before, *::after { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; }
body {
  margin: 0;
  font-family: var(--font-body);
  font-size: 1rem;
  line-height: 1.6;
  color: var(--text);
  background: var(--bg);
  -webkit-font-smoothing: antialiased;
}
img, svg, picture, video { display: block; max-width: 100%; height: auto; }
button { font: inherit; cursor: pointer; }
a { color: var(--primary); text-decoration: underline; text-underline-offset: 0.15em; transition: color 150ms ease-out; }
a:hover { color: var(--accent); }

/* Typography */
h1, h2, h3, h4, h5, h6 {
  font-family: var(--font-heading);
  font-weight: 600;
  line-height: 1.1;
  letter-spacing: -0.02em;
  margin: 0 0 0.75rem;
  color: var(--neutral-900);
}
h1 { font-size: clamp(2.25rem, 4.5vw, 3.5rem); font-weight: 700; }
h2 { font-size: clamp(1.5rem, 3vw, 2.125rem); margin-top: 2.5rem; }
h3 { font-size: 1.25rem; margin-top: 1.5rem; }
h4 { font-size: 1.0625rem; }
p { margin: 0 0 1rem; }
ul, ol { margin: 0 0 1rem; padding-left: 1.25rem; }
li { margin-bottom: 0.35rem; }
strong { font-weight: 600; color: var(--neutral-900); }

code, .mono {
  font-family: var(--font-mono);
  font-size: 0.875em;
}
code {
  background: var(--neutral-50);
  padding: 0.1em 0.35em;
  border-radius: var(--radius-tag);
  color: var(--primary-900);
}

sup { font-size: 0.7em; vertical-align: super; line-height: 0; }
sup a { text-decoration: none; font-weight: 500; color: var(--accent); padding: 0 0.1em; }

/* Layout container */
.container {
  width: 100%;
  max-width: var(--max-width);
  margin: 0 auto;
  padding-left: var(--container-px);
  padding-right: var(--container-px);
}

/* Site header */
.site-header {
  background: var(--bg);
  border-bottom: var(--rule);
  position: sticky;
  top: 0;
  z-index: 100;
}
.site-header > .container {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 1rem;
  min-height: 4rem;
  padding-top: 0.75rem;
  padding-bottom: 0.75rem;
}
.site-brand {
  font-family: var(--font-heading);
  font-weight: 700;
  font-size: 1.0625rem;
  letter-spacing: -0.01em;
  color: var(--neutral-900);
  text-decoration: none;
  display: flex;
  align-items: baseline;
  gap: 0.5rem;
  flex: 0 0 auto;
}
.site-brand::before {
  content: "[md]";
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  color: var(--accent);
  letter-spacing: 0;
  text-transform: lowercase;
}

/* Nav */
.site-nav { flex: 1 1 auto; display: flex; justify-content: flex-end; }
.site-nav ul {
  list-style: none;
  margin: 0;
  padding: 0;
  display: none;
  align-items: center;
  gap: 0;
}
.site-nav li {
  margin: 0;
  display: flex;
  align-items: center;
}
.site-nav li + li::before {
  content: "|";
  color: var(--neutral-200);
  padding: 0 0.5rem;
  font-family: var(--font-mono);
}
.site-nav a {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  text-decoration: none;
  color: var(--text);
  padding: 0.5rem 0.25rem;
}
.site-nav a:hover, .site-nav a[aria-current="page"] {
  color: var(--accent);
}

/* Mobile nav toggle */
.nav-toggle {
  display: inline-flex;
  flex-direction: column;
  justify-content: center;
  width: 2.25rem;
  height: 2.25rem;
  background: transparent;
  border: 1px solid var(--neutral-200);
  border-radius: var(--radius-button);
  padding: 0;
  gap: 4px;
  align-items: center;
}
.nav-toggle span {
  display: block;
  width: 1rem;
  height: 1.5px;
  background: var(--primary);
}
.site-nav.open ul {
  display: flex;
  flex-direction: column;
  align-items: stretch;
  position: absolute;
  top: 100%;
  left: 0;
  right: 0;
  background: var(--surface);
  border-bottom: var(--rule);
  padding: 0.5rem var(--container-px) 1rem;
  gap: 0;
}
.site-nav.open li { display: block; border-bottom: var(--rule); }
.site-nav.open li:last-child { border-bottom: none; }
.site-nav.open li + li::before { display: none; }
.site-nav.open a { display: block; padding: 0.75rem 0; }

@media (min-width: 768px) {
  .nav-toggle { display: none; }
  .site-nav ul { display: flex; flex-direction: row; }
}

/* Main + article */
main { padding-top: 2rem; padding-bottom: 4rem; }
article { display: block; }

/* Hero */
.hero {
  padding-top: 2rem;
  padding-bottom: 2.5rem;
  margin-bottom: 2rem;
  border-bottom: var(--rule);
}
.hero .container { display: block; }
.hero-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 2rem;
  align-items: start;
}
@media (min-width: 1024px) {
  .hero-grid { grid-template-columns: 1.45fr 1fr; gap: 3rem; }
}
.hero-main { display: block; }
.eyebrow {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--accent);
  margin: 0 0 1rem;
}
.hero h1 { margin-bottom: 1rem; }
.subheadline {
  font-size: 1.0625rem;
  color: var(--text-muted);
  max-width: 36em;
  margin-bottom: 1.75rem;
}
@media (min-width: 768px) {
  .subheadline { font-size: 1.125rem; }
}
.cta-row {
  display: flex;
  flex-wrap: wrap;
  gap: 0.75rem;
  margin-top: 1.5rem;
}

/* Buttons */
.btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  padding: 0.75rem 1.25rem;
  font-family: var(--font-body);
  font-size: 0.9375rem;
  font-weight: 500;
  letter-spacing: 0.02em;
  text-decoration: none;
  border-radius: var(--radius-button);
  border: 1px solid transparent;
  transition: background-color 150ms ease-out, color 150ms ease-out, border-color 150ms ease-out;
  cursor: pointer;
}
.btn-primary { background: var(--primary); color: #fff; }
.btn-primary:hover { background: var(--primary-900); color: #fff; }
.btn-secondary {
  background: transparent;
  color: var(--primary);
  border-color: var(--primary);
}
.btn-secondary:hover { background: var(--primary-50); color: var(--primary); }

/* Data strip */
.data-strip {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  border-top: var(--rule);
  border-bottom: var(--rule);
  margin: 2rem 0 0;
  background: var(--surface);
}
@media (min-width: 768px) {
  .data-strip { grid-template-columns: repeat(4, 1fr); }
}
.data-strip .cell {
  padding: 1rem 1.25rem;
  border-right: var(--rule);
  border-bottom: var(--rule);
}
.data-strip .cell:last-child { border-right: none; }
@media (min-width: 768px) {
  .data-strip .cell { border-bottom: none; }
  .data-strip .cell:nth-child(2) { border-right: var(--rule); }
}
.data-strip .label {
  display: block;
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin-bottom: 0.35rem;
}
.data-strip .value {
  display: block;
  font-family: var(--font-heading);
  font-size: 1.5rem;
  font-weight: 600;
  line-height: 1.1;
  color: var(--neutral-900);
  letter-spacing: -0.02em;
}
.data-strip .value .unit {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  font-weight: 500;
  color: var(--text-muted);
  margin-left: 0.25rem;
  letter-spacing: 0;
}

/* Hero data card */
.hero-data-card {
  background: var(--surface);
  border: var(--rule);
  border-radius: var(--radius-card);
  padding: 1.5rem;
  position: relative;
}
.hero-data-card .card-label {
  display: block;
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 0.5rem;
}
.hero-data-card .card-title {
  font-family: var(--font-heading);
  font-size: 1rem;
  font-weight: 600;
  margin: 0 0 1rem;
  color: var(--neutral-900);
}
.hero-data-card dl {
  margin: 0;
  display: block;
}
.hero-data-card dt {
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin: 0 0 0.15rem;
}
.hero-data-card dd {
  margin: 0 0 0.75rem;
  padding-bottom: 0.75rem;
  border-bottom: var(--rule);
  font-family: var(--font-mono);
  font-size: 0.9375rem;
  color: var(--neutral-900);
}
.hero-data-card dd:last-of-type { border-bottom: none; margin-bottom: 0; padding-bottom: 0; }
.hero-data-card dd strong {
  font-family: var(--font-heading);
  font-weight: 600;
  font-size: 1.0625rem;
  color: var(--neutral-900);
}

/* Sections */
section { margin-top: 2.5rem; }
section:first-of-type { margin-top: 0; }
section > h2:first-child { margin-top: 0; }

/* Figures */
figure { margin: 1.5rem 0; }
.hero-figure { margin: 0; }
.hero-figure img {
  width: 100%;
  border-radius: var(--radius-card);
  border: var(--rule);
}
.inline-figure img {
  border-radius: var(--radius-card);
  border: var(--rule);
}
figcaption {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  color: var(--text-muted);
  letter-spacing: 0.04em;
  text-transform: uppercase;
  margin-top: 0.5rem;
}

/* Callouts */
.callout {
  background: var(--surface);
  border-left: 3px solid var(--accent);
  padding: 1rem 1.25rem;
  margin: 1.5rem 0;
  border-radius: 0 var(--radius-card) var(--radius-card) 0;
  border-top: var(--rule);
  border-right: var(--rule);
  border-bottom: var(--rule);
}
.callout .callout-label {
  display: block;
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 0.5rem;
}
.callout p:last-child { margin-bottom: 0; }
.callout.warning { border-left-color: var(--warning); background: var(--neutral-50); }
.callout.warning .callout-label { color: var(--warning); }
.callout.danger { border-left-color: var(--danger); background: var(--neutral-50); }
.callout.danger .callout-label { color: var(--danger); }

/* Cards */
.card {
  background: var(--surface);
  border: var(--rule);
  border-radius: var(--radius-card);
  padding: 1.5rem;
  margin: 1.5rem 0;
}
.card-eyebrow {
  display: block;
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin-bottom: 0.5rem;
}
.card h3 { margin-top: 0; }

/* Trial card */
.trial-card {
  background: var(--surface);
  border: var(--rule);
  border-radius: var(--radius-card);
  padding: 1.5rem;
  margin: 1.5rem 0;
  transition: border-color 200ms ease-out;
}
.trial-card:hover { border-color: var(--primary); }
.trial-card .trial-label {
  display: block;
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 0.4rem;
}
.trial-card h3 { margin-top: 0; margin-bottom: 1rem; font-size: 1.375rem; }
.trial-meta {
  display: grid;
  grid-template-columns: 1fr;
  gap: 0.75rem 1.5rem;
  margin: 0 0 1rem;
  padding: 1rem 0;
  border-top: var(--rule);
  border-bottom: var(--rule);
}
@media (min-width: 600px) {
  .trial-meta { grid-template-columns: repeat(2, 1fr); }
}
.trial-meta div { margin: 0; }
.trial-meta dt {
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin: 0 0 0.15rem;
}
.trial-meta dd {
  font-family: var(--font-body);
  font-size: 0.9375rem;
  margin: 0;
  color: var(--neutral-900);
}
.trial-outcome {
  background: var(--neutral-50);
  border-left: 3px solid var(--accent);
  padding: 0.875rem 1.125rem;
  margin-top: 1rem;
  border-radius: 0 var(--radius-tag) var(--radius-tag) 0;
}
.trial-outcome .outcome-label {
  display: block;
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 0.35rem;
}
.trial-outcome p { margin: 0; font-size: 0.9375rem; }

/* Tags */
.tag {
  display: inline-block;
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--primary);
  background: transparent;
  border: 1px solid var(--primary);
  padding: 0.2rem 0.5rem;
  border-radius: var(--radius-tag);
  margin: 0 0.25rem 0.25rem 0;
  text-decoration: none;
  line-height: 1;
}

/* Tables */
table {
  width: 100%;
  border-collapse: collapse;
  margin: 1.5rem 0;
  font-size: 0.9375rem;
}
thead th {
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-muted);
  text-align: left;
  padding: 0.625rem 0.75rem;
  border-bottom: 1px solid var(--primary);
}
tbody td {
  padding: 0.75rem;
  border-bottom: var(--rule);
  vertical-align: top;
}
tbody tr:last-child td { border-bottom: none; }

/* References list */
.references-list {
  list-style: none;
  padding: 0;
  margin: 0;
  counter-reset: ref-counter;
}
.references-list li {
  position: relative;
  padding: 1rem 0 1rem 3.25rem;
  border-bottom: var(--rule);
  font-size: 0.9375rem;
  counter-increment: ref-counter;
}
.references-list li::before {
  content: "[" counter(ref-counter) "]";
  position: absolute;
  left: 0;
  top: 1rem;
  font-family: var(--font-mono);
  font-size: 0.8125rem;
  font-weight: 500;
  color: var(--accent);
  letter-spacing: 0.02em;
}
.references-list li:target {
  background: var(--primary-50);
  padding-left: 3.5rem;
  margin-left: -0.25rem;
  padding-right: 0.5rem;
}
.references-list a.ext-link {
  margin-left: 0.35rem;
  text-decoration: none;
  font-family: var(--font-mono);
  color: var(--accent);
}
.references-list .doi {
  display: block;
  font-family: var(--font-mono);
  font-size: 0.75rem;
  color: var(--text-muted);
  margin-top: 0.25rem;
  letter-spacing: 0;
}

/* FAQ — q/a layout */
.faq-list { list-style: none; padding: 0; margin: 0; }
.faq-list > section { margin-top: 1.5rem; padding-top: 1.5rem; border-top: var(--rule); }
.faq-list > section:first-child { border-top: none; padding-top: 0; margin-top: 0; }

/* Indication tag row */
.indication-row {
  display: flex;
  flex-wrap: wrap;
  gap: 0.4rem;
  margin: 1rem 0 1.5rem;
}

/* Forms */
form { margin: 1.5rem 0; }
.field { margin-bottom: 1rem; }
.field label {
  display: block;
  font-family: var(--font-mono);
  font-size: 0.75rem;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin-bottom: 0.35rem;
}
.field input, .field textarea {
  width: 100%;
  padding: 0.625rem 0.75rem;
  font-family: var(--font-body);
  font-size: 0.9375rem;
  background: var(--surface);
  border: var(--rule);
  border-radius: var(--radius-tag);
  color: var(--text);
}
.field input:focus, .field textarea:focus {
  outline: none;
  border-color: var(--primary);
  box-shadow: 0 0 0 2px var(--primary-50);
}
.form-note {
  font-size: 0.8125rem;
  color: var(--text-muted);
  margin-top: 0.75rem;
}

/* Footer */
.site-footer {
  background: var(--primary-900);
  color: #C8D2DE;
  padding: 3rem 0 2rem;
  margin-top: 4rem;
  border-top: 1px solid var(--primary-900);
}
.site-footer a { color: #DBE2EC; text-decoration: none; }
.site-footer a:hover { color: var(--accent); text-decoration: underline; }
.footer-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 2rem;
  margin-bottom: 2rem;
}
@media (min-width: 720px) {
  .footer-grid { grid-template-columns: 1.4fr 1fr 1fr 1fr; }
}
.footer-brand {
  font-family: var(--font-heading);
  font-weight: 700;
  font-size: 1.0625rem;
  color: #fff;
  margin-bottom: 0.5rem;
}
.footer-tagline {
  font-size: 0.8125rem;
  color: #95A2B0;
  margin: 0;
  max-width: 24em;
}
.footer-col h4 {
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: #95A2B0;
  margin: 0 0 0.875rem;
}
.footer-col ul { list-style: none; padding: 0; margin: 0; }
.footer-col li { margin-bottom: 0.5rem; }
.footer-col a {
  font-family: var(--font-body);
  font-size: 0.875rem;
}
.footer-bottom {
  border-top: 1px solid #1F3144;
  padding-top: 1.5rem;
  display: flex;
  flex-direction: column;
  gap: 0.75rem;
}
@media (min-width: 720px) {
  .footer-bottom { flex-direction: row; justify-content: space-between; align-items: flex-start; }
}
.disclaimer {
  font-size: 0.8125rem;
  color: #95A2B0;
  max-width: 60em;
  margin: 0;
  line-height: 1.5;
}
.copyright {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  color: #95A2B0;
  margin: 0;
  letter-spacing: 0.02em;
}

/* 404 */
.page-404 {
  min-height: 60vh;
  display: flex;
  align-items: center;
  justify-content: center;
}
.page-404 .container { text-align: center; padding-top: 3rem; padding-bottom: 3rem; }
.page-404 .err-code {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  font-weight: 500;
  color: var(--accent);
  letter-spacing: 0.08em;
  text-transform: uppercase;
}
.page-404 h1 { font-size: clamp(2rem, 5vw, 3rem); margin: 1rem 0; }

/* Utility */
.lead { font-size: 1.0625rem; color: var(--text-muted); }
.muted { color: var(--text-muted); }
.mono-data { font-family: var(--font-mono); }

/* Inline mono data values inside body copy */
article code { font-size: 0.875em; }

/* Sticky right-side metadata sidebar */
.with-sidebar {
  display: grid;
  grid-template-columns: 1fr;
  gap: 2rem;
}
@media (min-width: 1024px) {
  .with-sidebar { grid-template-columns: 1fr 18rem; gap: 3rem; align-items: start; }
}
.sidebar {
  background: var(--surface);
  border: var(--rule);
  border-radius: var(--radius-card);
  padding: 1.25rem;
  position: sticky;
  top: 5rem;
}
.sidebar h4 {
  font-family: var(--font-mono);
  font-size: 0.6875rem;
  font-weight: 500;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin: 0 0 0.75rem;
}
.sidebar ul { list-style: none; padding: 0; margin: 0; }
.sidebar li { margin-bottom: 0.5rem; font-size: 0.875rem; }
.sidebar li a { text-decoration: none; }
.sidebar li a:hover { text-decoration: underline; }
.sidebar .meta-row {
  display: flex;
  justify-content: space-between;
  align-items: baseline;
  font-family: var(--font-mono);
  font-size: 0.75rem;
  padding: 0.4rem 0;
  border-bottom: var(--rule);
}
.sidebar .meta-row:last-child { border-bottom: none; }
.sidebar .meta-row .k { color: var(--text-muted); text-transform: uppercase; letter-spacing: 0.06em; }
.sidebar .meta-row .v { color: var(--neutral-900); font-weight: 500; }

/* Utility variants */
.cta-row.center { justify-content: center; }
.cta-row.spaced-top { margin-top: 3rem; }
.trial-meta.single-col {
  grid-template-columns: 1fr;
  margin: 0;
  padding: 0;
  border: none;
}
@media (min-width: 600px) {
  .trial-meta.single-col { grid-template-columns: 1fr; }
}

/* Reduced motion */
@media (prefers-reduced-motion: reduce) {
  *, *::before, *::after { transition-duration: 0.01ms !important; animation-duration: 0.01ms !important; }
}